Structure of PDB 8xt2 Chain Lb

Receptor sequence
>8xt2Lb (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
PLHKYPVWLWKRLQLREGICSRLPGHYLRSLEEERTPTPVHYRPHGAKFK
INPKNGQRERVEDVPIPIYFPPESQRGLWGGEGWILGQIYANNDKLSKRL
KKVWKPQLFEREFYSEILDKKFTVTVTMRTLDLIDEAYGLDFYILKTPKE
DLCSKFGMDLKRGMLLRLARQDPQLHPEDPERRAAIYDKYKEFAIPEEEA
EWVGLTLEEAIEKQRLLEEKDPVPLFKIYVAELIQQLQQQALS
3D structure
PDB8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLb
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Lb L3 H4 K5 Y6 W9 L14 E18 K55 Y70 P73 L87 G88 Q89 Y91 N93 K96 L97 S98 K99 L101 K102 K103 V104 W105 K106 Q108 F110 R112 L2 H3 K4 Y5 W8 L13 E17 K54 Y69 P72 L86 G87 Q88 Y90 N92 K95 L96 S97 K98 L100 K101 K102 V103 W104 K105 Q107 F109 R111
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005829 cytosol
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum8xt2
PubMed38942792
UniProtQ13084|RM28_HUMAN Large ribosomal subunit protein bL28m (Gene Name=MRPL28)

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