Structure of PDB 8xt0 Chain La

Receptor sequence
>8xt0La (length=111) Species: 9606 (Homo sapiens) [Search protein sequence]
SSKNLGGKSSGRRQGIKKMEGHYVHAGNIIATQRHFRWHPGAHVGVGKNK
CLYALEEGIVRYTKEVYVPHPRNTEAVDLITRLPKGAVLYKTFVHVVPAK
PEGTFKLVAML
3D structure
PDB8xt0 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLa
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna La N41 L42 G43 G44 S46 G48 R49 R50 Q51 K54 M56 E57 H59 A63 G64 N65 I66 R71 R74 W75 K85 N86 Y90 Y99 K101 N4 L5 G6 G7 S9 G11 R12 R13 Q14 K17 M19 E20 H22 A26 G27 N28 I29 R34 R37 W38 K48 N49 Y53 Y62 K64
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Cellular Component
External links
PDB RCSB:8xt0, PDBe:8xt0, PDBj:8xt0
PDBsum8xt0
PubMed38942792
UniProtQ9P0M9|RM27_HUMAN Large ribosomal subunit protein bL27m (Gene Name=MRPL27)

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