Structure of PDB 8xsy Chain La

Receptor sequence

>8xsyLa (length=147) Species: 9606 (Homo sapiens)

PSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGLHHHRINFDKYHPG
YFGKVGMKHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPII
DVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKSVGGACVLVA

3D structure

• PDB: 8xsy Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
• Chain: La
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	La	P2 S3 R4 R6 K7 T8 R9 K10 R12 H14 V15 H17 G18 H19 G20 R21 I22 G23 H25 R26 K27 H28 P29 G30 G31 R32 G33 N34 G36 H39 H40 H41 R42 I43 N44 K47 Y52 F53 G54 K55 V56 G57 M58 K59 H60 Y61 H62 L63 K64 R65 N66 Q67 T72 N74 K77 V82 S83 Q85 T86 I101 D102 R105 S106 K110 L112 G113 K114 G115 K116 S130 R131 R132	P1 S2 R3 R5 K6 T7 R8 K9 R11 H13 V14 H16 G17 H18 G19 R20 I21 G22 H24 R25 K26 H27 P28 G29 G30 R31 G32 N33 G35 H38 H39 H40 R41 I42 N43 K46 Y51 F52 G53 K54 V55 G56 M57 K58 H59 Y60 H61 L62 K63 R64 N65 Q66 T71 N73 K76 V81 S82 Q84 T85 I100 D101 R104 S105 K109 L111 G112 K113 G114 K115 S129 R130 R131

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8xsy, PDBe:8xsy, PDBj:8xsy
• PDBsum: 8xsy
• PubMed: 38942792
• UniProt: P46776|RL27A_HUMAN Large ribosomal subunit protein uL15 (Gene Name=RPL27A)