Structure of PDB 7zjw Chain La

Receptor sequence

>7zjwLa (length=118) Species: 9986 (Oryctolagus cuniculus)

KIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMK
KIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYV
RLAPDYDALDVANKIGII

3D structure

• PDB: 7zjw Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.
• Chain: La
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	La	K39 P44 T45 F46 R47 R48 K50 T51 R53 R56 K59 Y60 R62 T83 K89 N105 K106 H107 K123 N125 I128 P130 K134 Y137 R139	K1 P6 T7 F8 R9 R10 K12 T13 R15 R18 K21 Y22 R24 T45 K51 N67 K68 H69 K85 N87 I90 P92 K96 Y99 R101
BS02	rna	La	T51 L52 R56 K63 P66 R67 R68 K70 H107 Q108	T13 L14 R18 K25 P28 R29 R30 K32 H69 Q70

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7zjw, PDBe:7zjw, PDBj:7zjw
• PDBsum: 7zjw
• PubMed: 35709277
• UniProt: G1SE76|RL23A_RABIT Large ribosomal subunit protein uL23 (Gene Name=RPL23A)