Structure of PDB 8yop Chain LZ

Receptor sequence
>8yopLZ (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]
GKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPR
KVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVF
RDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF
3D structure
PDB8yop Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLZ
Resolution2.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LZ A15 G16 R17 R36 Y38 R48 R51 K52 T54 A55 G58 K59 K64 R65 K67 K69 K73 V74 Y75 N76 N78 H79 K107 R111 R112 K115 K133 R135 F136 A14 G15 R16 R35 Y37 R47 R50 K51 T53 A54 G57 K58 K63 R64 K66 K68 K72 V73 Y74 N75 N77 H78 K106 R110 R111 K114 K132 R134 F135
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:1904044 response to aldosterone
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8yop, PDBe:8yop, PDBj:8yop
PDBsum8yop
PubMed38942792
UniProtP61353|RL27_HUMAN Large ribosomal subunit protein eL27 (Gene Name=RPL27)

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