Structure of PDB 8xt3 Chain LX

Receptor sequence
>8xt3LX (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
LPPHYRYGMSPPGSVADKRKNPPWIRRRPVVVEPISDEDWYLFCGDTVEI
LEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTMDYRGTMIPSEAP
LLHRQVKLVDPMDRKPTEIEWRFTEAGERVRVSTRSGRIIPKPEFPRADG
IVPETWIDGPKDTSVEDALERTYVPCLKTLQEEVMEAMGIKETRKYKKVY
WY
3D structure
PDB8xt3 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLX
Resolution3.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LX H18 R20 M23 K34 R40 R41 R42 P43 R83 W85 H94 R96 S111 P114 H4 R6 M9 K20 R26 R27 R28 P29 R69 W71 H80 R82 S97 P100
Gene Ontology
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8xt3, PDBe:8xt3, PDBj:8xt3
PDBsum8xt3
PubMed38942792
UniProtQ96A35|RM24_HUMAN Large ribosomal subunit protein uL24m (Gene Name=MRPL24)

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