Structure of PDB 8oj8 Chain LX

Receptor sequence

>8oj8LX (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]

KIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMK
KIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYV
RLAPDYDALDVANKIGII

3D structure

PDB

8oj8 UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER

Chain

Resolution

3.3 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LX	P44 T45 R47 R48 K50 T51 R53 L54 R56 Q57 P58 K59 Y60 R62 T83 S85 N93 N105 K106 H107 K123 N125 T126 L127 I128 P130 K134 K135 Y137 R139	P6 T7 R9 R10 K12 T13 R15 L16 R18 Q19 P20 K21 Y22 R24 T45 S47 N55 N67 K68 H69 K85 N87 T88 L89 I90 P92 K96 K97 Y99 R101
BS02	rna	LX	P49 T51 L52 R56 P66 R67 R68 K70 H107 Q108	P11 T13 L14 R18 P28 R29 R30 K32 H69 Q70

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0045296	cadherin binding
GO:1904841	TORC2 complex binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8oj8, PDBe:8oj8, PDBj:8oj8
PDBsum	8oj8
PubMed	38383785
UniProt	P62750\|RL23A_HUMAN Large ribosomal subunit protein uL23 (Gene Name=RPL23A)