Structure of PDB 8g61 Chain LX

Receptor sequence

>8g61LX (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]

KIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMK
KIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYV
RLAPDYDALDVANKIGII

3D structure

PDB

8g61 mRNA decoding in human is kinetically and structurally distinct from bacteria.

Chain

Resolution

2.94 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LX	F46 P49 T51 L52 R55 R56 K63 P66 R67 N69 K70 V102 K103 H107 Q108 Q111	F8 P11 T13 L14 R17 R18 K25 P28 R29 N31 K32 V64 K65 H69 Q70 Q73
BS02	rna	LX	P44 T45 F46 R47 R48 P49 K50 T51 R53 L54 R56 Q57 K59 Y60 R62 T83 S85 K89 N105 K106 H107 K123 N125 T126 L127 I128 P130 K134 K135 Y137 R139	P6 T7 F8 R9 R10 P11 K12 T13 R15 L16 R18 Q19 K21 Y22 R24 T45 S47 K51 N67 K68 H69 K85 N87 T88 L89 I90 P92 K96 K97 Y99 R101

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0045296	cadherin binding
GO:1904841	TORC2 complex binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8g61, PDBe:8g61, PDBj:8g61
PDBsum	8g61
PubMed	37020024
UniProt	P62750\|RL23A_HUMAN Large ribosomal subunit protein uL23 (Gene Name=RPL23A)