Structure of PDB 8xsx Chain LW

Receptor sequence
>8xsxLW (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]
MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQIN
WTVLYRRKHKKGQKRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQRE
QAIRAAKEAKKAKQASKK
3D structure
PDB8xsx Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLW
Resolution2.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LW G16 G18 R19 K35 R44 I49 N50 W51 R56 K61 G16 G18 R19 K35 R44 I49 N50 W51 R56 K61
BS02 rna LW K70 R71 R73 R74 R80 K113 K123 K124 K64 R65 R67 R68 R74 K107 K117 K118
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0045296 cadherin binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0010458 exit from mitosis
GO:0021554 optic nerve development
GO:0031290 retinal ganglion cell axon guidance
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Cellular Component
External links
PDB RCSB:8xsx, PDBe:8xsx, PDBj:8xsx
PDBsum8xsx
PubMed38942792
UniProtP83731|RL24_HUMAN Large ribosomal subunit protein eL24 (Gene Name=RPL24)

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