Structure of PDB 8fkw Chain LW

Receptor sequence

>8fkwLW (length=74) Species: 9606 (Homo sapiens) [Search protein sequence]

KTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTGTGR
MRHLKIVYRRFRHGFREGTTPKPK

3D structure

PDB

8fkw Principles of human pre-60 S biogenesis.

Chain

Resolution

2.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	LW	R20 R21 Y27 Y39 T59 G62 R63 M64 R65 H66 L67 K68 R72 F74 H76 R79 E80 G81 T82 T83 P84 K85 K87	R7 R8 Y14 Y26 T46 G49 R50 M51 R52 H53 L54 K55 R59 F61 H63 R66 E67 G68 T69 T70 P71 K72 K74
BS02	rna	LW	T15 H16 H28 K31 R43 K44 R45 K46 Y47 N48 W49 K52 R55 R56 T58 T59 Y71 K85	T2 H3 H15 K18 R30 K31 R32 K33 Y34 N35 W36 K39 R42 R43 T45 T46 Y58 K72
BS03	ZN	LW	C19 C22 C34 C37	C6 C9 C21 C24

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding
GO:0046872	metal ion binding
GO:0097371	MDM2/MDM4 family protein binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:1901798	positive regulation of signal transduction by p53 class mediator

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8fkw, PDBe:8fkw, PDBj:8fkw
PDBsum	8fkw
PubMed	37410842
UniProt	P61927\|RL37_HUMAN Large ribosomal subunit protein eL37 (Gene Name=RPL37)