Structure of PDB 6zme Chain LW

Receptor sequence

>6zmeLW (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]

MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQIN
WTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEV
RKAQREQAIRAAKEAKKAKQASKK

3D structure

PDB

6zme Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.

Chain

Resolution

3.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LW	G16 G18 K35 R44 I49 N50 W51 R56 K61	G16 G18 K35 R44 I49 N50 W51 R56 K61
BS02	rna	LW	Q68 K70 R71 T72 R73 R74 R80 K113 K116 K123	Q68 K70 R71 T72 R73 R74 R80 K113 K116 K123

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0045296	cadherin binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0010458	exit from mitosis
GO:0021554	optic nerve development
GO:0031290	retinal ganglion cell axon guidance
GO:0060041	retina development in camera-type eye

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6zme, PDBe:6zme, PDBj:6zme
PDBsum	6zme
PubMed	32680882
UniProt	P83731\|RL24_HUMAN Large ribosomal subunit protein eL24 (Gene Name=RPL24)