Structure of PDB 8xt2 Chain LV

Receptor sequence

>8xt2LV (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]

ISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRG
MSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEFRSNLYIAEST
SGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPPPEPPKTAVAHA
KEYIQQLRSRTIVHTL

3D structure

PDB

8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LV	I47 S48 R49 K50 W51 K53 K54 K56 R78 K81 Y82 S83 K86 W88 R95 D110 K111 K112 T146 R149 Q151 K154 R157 Y158 H159 G160 R161 G162 R163 M167 E168 K169 V170 H173 S205 R206 T207 V209 H210	I1 S2 R3 K4 W5 K7 K8 K10 R32 K35 Y36 S37 K40 W42 R49 D64 K65 K66 T100 R103 Q105 K108 R111 Y112 H113 G114 R115 G116 R117 M121 E122 K123 V124 H127 S159 R160 T161 V163 H164

Gene Ontology

	Cellular Component
GO:0005739	mitochondrion
GO:0005840	ribosome
GO:1990904	ribonucleoprotein complex

View graph for
Cellular Component

External links

PDB	RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum	8xt2
PubMed	38942792
UniProt	E7ESL0

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