Structure of PDB 8xsy Chain LV

Receptor sequence
>8xsyLV (length=131) Species: 9606 (Homo sapiens) [Search protein sequence]
SGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGD
MVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNK
GEMKGSAITGPVAKECADLWPRIASNAGSIA
3D structure
PDB8xsy Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLV
Resolution3.0 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LV A12 K13 F14 R15 S17 G19 P21 G23 A24 V25 I40 S41 K43 G44 I45 K46 R48 L49 N50 R51 L52 T64 K66 K74 V76 R85 K86 F95 A3 K4 F5 R6 S8 G10 P12 G14 A15 V16 I31 S32 K34 G35 I36 K37 R39 L40 N41 R42 L43 T55 K57 K65 V67 R76 K77 F86
Gene Ontology
Molecular Function
GO:0001223 transcription coactivator binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0070180 large ribosomal subunit rRNA binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006610 ribosomal protein import into nucleus
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0032986 protein-DNA complex disassembly
GO:0050821 protein stabilization
GO:0070314 G1 to G0 transition
GO:0072717 cellular response to actinomycin D
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1903450 regulation of G1 to G0 transition
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0032991 protein-containing complex
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xsy, PDBe:8xsy, PDBj:8xsy
PDBsum8xsy
PubMed38942792
UniProtP62829|RL23_HUMAN Large ribosomal subunit protein uL14 (Gene Name=RPL23)

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