Structure of PDB 8glp Chain LV

Receptor sequence

>8glpLV (length=133) Species: 9606 (Homo sapiens) [Search protein sequence]

GSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGV
GDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVN
NKGEMKGSAITGPVAKECADLWPRIASNAGSIA

3D structure

PDB

8glp mRNA decoding in human is kinetically and structurally distinct from bacteria.

Chain

Resolution

1.67 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LV	G8 S9 S10 A12 F14 R15 S17 G19 P21 V22 A24 V25 Y38 I40 S41 K43 G44 I45 K46 R48 L49 N50 R51 L52 M62 T64 K66 K74 V76 R85 K86 R89 F95	G1 S2 S3 A5 F7 R8 S10 G12 P14 V15 A17 V18 Y31 I33 S34 K36 G37 I38 K39 R41 L42 N43 R44 L45 M55 T57 K59 K67 V69 R78 K79 R82 F88

Gene Ontology

	Molecular Function
GO:0001223	transcription coactivator binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0070180	large ribosomal subunit rRNA binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006610	ribosomal protein import into nucleus
GO:0008284	positive regulation of cell population proliferation
GO:0010628	positive regulation of gene expression
GO:0032986	protein-DNA complex disassembly
GO:0050821	protein stabilization
GO:0070314	G1 to G0 transition
GO:0072717	cellular response to actinomycin D
GO:1901798	positive regulation of signal transduction by p53 class mediator
GO:1903450	regulation of G1 to G0 transition
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process

	Cellular Component
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8glp, PDBe:8glp, PDBj:8glp
PDBsum	8glp
PubMed	37020024
UniProt	P62829\|RL23_HUMAN Large ribosomal subunit protein uL14 (Gene Name=RPL23)