Structure of PDB 7cpu Chain LV

Receptor sequence

>7cpuLV (length=130) Species: 10090 (Mus musculus) [Search protein sequence]

GAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDM
VMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKG
EMKGSAITGPVAKECADLWPRIASNAGSIA

3D structure

PDB

7cpu A male germ-cell-specific ribosome controls male fertility.

Chain

Resolution

2.82 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	LV	A12 K13 F14 R15 S17 G19 P21 G23 A24 V25 I40 S41 V42 K43 G44 I45 K46 R48 L49 N50 R51 L52 M62 T64 K66 K74 V76 R85 K86 R89 F95	A2 K3 F4 R5 S7 G9 P11 G13 A14 V15 I30 S31 V32 K33 G34 I35 K36 R38 L39 N40 R41 L42 M52 T54 K56 K64 V66 R75 K76 R79 F85
BS02	rna	LV	K35 K67 P70 R131 S134	K25 K57 P60 R121 S124
BS03	MG	LV	I45 K46	I35 K36

Gene Ontology

	Molecular Function
GO:0001223	transcription coactivator binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0008284	positive regulation of cell population proliferation
GO:0010628	positive regulation of gene expression
GO:0032986	protein-DNA complex disassembly
GO:0050821	protein stabilization
GO:0070314	G1 to G0 transition
GO:0072717	cellular response to actinomycin D
GO:0140236	translation at presynapse
GO:0140242	translation at postsynapse
GO:1901798	positive regulation of signal transduction by p53 class mediator
GO:1903450	regulation of G1 to G0 transition
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process

	Cellular Component
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0045202	synapse
GO:0098793	presynapse
GO:0098794	postsynapse
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7cpu, PDBe:7cpu, PDBj:7cpu
PDBsum	7cpu
PubMed	36517592
UniProt	P62830\|RL23_MOUSE Large ribosomal subunit protein uL14 (Gene Name=Rpl23)