Structure of PDB 8xsy Chain LU

Receptor sequence
>8xsyLU (length=100) Species: 9606 (Homo sapiens) [Search protein sequence]
VLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSK
SKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQI
3D structure
PDB8xsy Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLU
Resolution3.0 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LU K48 N50 G51 S79 K80 R81 Y82 K84 Y85 K89 K92 R97 R101 V103 A104 K107 R113 K31 N33 G34 S62 K63 R64 Y65 K67 Y68 K72 K75 R80 R84 V86 A87 K90 R96
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0042802 identical protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0046632 alpha-beta T cell differentiation
GO:0140236 translation at presynapse
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8xsy, PDBe:8xsy, PDBj:8xsy
PDBsum8xsy
PubMed38942792
UniProtP35268|RL22_HUMAN Large ribosomal subunit protein eL22 (Gene Name=RPL22)

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