Structure of PDB 8y0w Chain LT

Receptor sequence

>8y0wLT (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]

TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKG
MPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKS
RDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELL
EPIPYEFMA

3D structure

PDB

8y0w dormant ribosome with eIF5A, eEF2 and SERBP1

Chain

Resolution

3.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LT	T2 N3 T4 K5 G6 K7 R8 R9 R12 Y13 S16 R17 H22 G23 D41 K43 T47 Q49 K50 G51 H54 K55 Y57 H58 G59 T61 T68 Q69 H70 K78 V80 K81 K87 R88 R92 S101 R102 S104 F105 R108 N112 W125 V126 L128 K129 R130 R142	T1 N2 T3 K4 G5 K6 R7 R8 R11 Y12 S15 R16 H21 G22 D40 K42 T46 Q48 K49 G50 H53 K54 Y56 H57 G58 T60 T67 Q68 H69 K77 V79 K80 K86 R87 R91 S100 R101 S103 F104 R107 N111 W124 V125 L127 K128 R129 R141
BS02	rna	LT	R20 P26 A28	R19 P25 A27

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

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Cellular Component

External links

PDB	RCSB:8y0w, PDBe:8y0w, PDBj:8y0w
PDBsum	8y0w
PubMed	38698775
UniProt	P46778\|RL21_HUMAN Large ribosomal subunit protein eL21 (Gene Name=RPL21)

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