Structure of PDB 7mq9 Chain LT

Receptor sequence

>7mq9LT (length=869) Species: 9606 (Homo sapiens)

RTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYDVQK
LSLVAVSNSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKA
EIHFLQPFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHP
STYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVA
IGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGH
IGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFD
GPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEK
FNKSLGHGLINKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIAC
HQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCGNFAVIGL
SSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLL
KFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRK
IVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLD
SAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSI
VMLPGTCQSDELIEYDSPEQLNEQLVTLSLLPESRWKNLLNLDVIKKKNK
PKEPPKVPKSAPFFIPTIPGLVPRYAAPEQPQQSKVVNLGVLAQKSDFCL
KLEEGLVNNKYDTALNLLKESGPSGIETELRSLSPDCGGSIEVMQSFLKM
IGMMLDRKRDFELAQAYLALFLKLHLKMLPSEPVLLEEITNLSSQVEENW
THLQSLFNQSMCILNYLKS

3D structure

• PDB: 7mq9 Nucleolar maturation of the human small subunit processome.
• Chain: LT
• Resolution: 3.87 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LT	A91 L92 K93 K113 S115 L136 A149 R150 Y190 L372 R375 E412 K413 N424 K426 R427 R430 S438 L468 S469 F484 K486 K491 D493	A28 L29 K30 K50 S52 L73 A86 R87 Y127 L309 R312 E349 K350 N361 K363 R364 R367 S375 L405 S406 F421 K423 K428 D430
BS02	rna	LT	S417 H420 L433 S478 T479	S354 H357 L370 S415 T416

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0006364 rRNA processing
• GO:0007601 visual perception
• GO:0008150 biological_process
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0032040 small-subunit processome
• GO:0034388 Pwp2p-containing subcomplex of 90S preribosome

External links

• PDB: RCSB:7mq9, PDBe:7mq9, PDBj:7mq9
• PDBsum: 7mq9
• PubMed: 34516797
• UniProt: Q8NI36|WDR36_HUMAN WD repeat-containing protein 36 (Gene Name=WDR36)