Structure of PDB 6z6l Chain LT

Receptor sequence

>6z6lLT (length=159) Species: 9606 (Homo sapiens)

TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKG
MPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKS
RDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELL
EPIPYEFMA

3D structure

• PDB: 6z6l Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
• Chain: LT
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LT	T2 N3 T4 K5 G6 K7 R8 R9 G10 R12 Y13 M14 S16 R17 F19 H22 G23 D41 K43 T47 Q49 G51 H54 K55 Y57 H58 G59 K60 T61 T68 Q69 H70 K78 V80 K81 K83 K87 R88 I89 N90 R92 K97 S101 R102 F105 R108 K110 D113 K116 W125 V126 L128 K129 R130 R142	T1 N2 T3 K4 G5 K6 R7 R8 G9 R11 Y12 M13 S15 R16 F18 H21 G22 D40 K42 T46 Q48 G50 H53 K54 Y56 H57 G58 K59 T60 T67 Q68 H69 K77 V79 K80 K82 K86 R87 I88 N89 R91 K96 S100 R101 F104 R107 K109 D112 K115 W124 V125 L127 K128 R129 R141
BS02	rna	LT	R20 P26 A28	R19 P25 A27

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6z6l, PDBe:6z6l, PDBj:6z6l
• PDBsum: 6z6l
• PubMed: 32687489
• UniProt: P46778|RL21_HUMAN Large ribosomal subunit protein eL21 (Gene Name=RPL21)