Structure of PDB 4ug0 Chain LT

Receptor sequence

>4ug0LT (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]

TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKG
MPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKS
RDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELL
EPIPYEFMA

3D structure

PDB

4ug0 Structure of the human 80S ribosome

Chain

Resolution

3.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LT	T2 N3 T4 K5 G6 K7 R8 R9 G10 R12 Y13 M14 S16 R17 H22 G23 D41 Q49 G51 H54 K55 Y57 H58 G59 K60 T61 Q69 H70 N77 K78 V80 K87 R88 N90 R92 K100 S101 R102 S104 F105 R108 V109 K110 N112 K129 R130 P132 F140 R142	T1 N2 T3 K4 G5 K6 R7 R8 G9 R11 Y12 M13 S15 R16 H21 G22 D40 Q48 G50 H53 K54 Y56 H57 G58 K59 T60 Q68 H69 N76 K77 V79 K86 R87 N89 R91 K99 S100 R101 S103 F104 R107 V108 K109 N111 K128 R129 P131 F139 R141
BS02	rna	LT	P26 L27 A28	P25 L26 A27

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4ug0, PDBe:4ug0, PDBj:4ug0
PDBsum	4ug0
PubMed	25901680
UniProt	P46778\|RL21_HUMAN Large ribosomal subunit protein eL21 (Gene Name=RPL21)

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