Structure of PDB 8xt1 Chain LS

Receptor sequence
>8xt1LS (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
RFLSPEFIPRRGRTDPLKFQIERKDMLERRKVLHIPEFYVGSILRVTTAD
PYASGKISQFLGICIQRSGRGLGATFILRNVIEGQGVEICFELYNPRVQE
IQVVKLEKRLDDSLLYLRDALPEYSTFDVNMKPVVQEPNQKVPVNELKVK
MKPKPWSKRWERPNFNIKGIRFDLCLTEQQMKEAQKWNQPWLEFDMMREY
DTSKIEAAIWKEIEASKRS
3D structure
PDB8xt1 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLS
Resolution3.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LS R83 R84 G85 R86 S141 R143 T148 W260 R10 R11 G12 R13 S68 R70 T75 W187
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt1, PDBe:8xt1, PDBj:8xt1
PDBsum8xt1
PubMed38942792
UniProtP49406|RM19_HUMAN Large ribosomal subunit protein bL19m (Gene Name=MRPL19)

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