Structure of PDB 8k2d Chain LS

Receptor sequence

>8k2dLS (length=172) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

MAHFKEYQVIGRRLPTESVPEPKLFRMRIFASNEVIAKSRYWYFLQKLHK
VKKASGEIVSINQINEAHPTKVKNFGVWVRYDSRSGTHNMYKEIRDVSRV
AAVETLYQDMAARHRARFRSIHILKVAEIEKTADVKRQYVKQFLTKDLKF
PLPHRVQKSTKTFSYKRPSTFY

3D structure

PDB

8k2d Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

3.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LS	M1 A2 N62 N65 E66 H68 S83 R84 S85 H88 Y91 Q108 A111 A112 R113 H114 R115 R117 T132 R137 L144 T145 K146 P153 H154 R155 K158 K161 Y165 K166 S169 T170 F171	M1 A2 N62 N65 E66 H68 S83 R84 S85 H88 Y91 Q108 A111 A112 R113 H114 R115 R117 T132 R137 L144 T145 K146 P153 H154 R155 K158 K161 Y165 K166 S169 T170 F171
BS02	rna	LS	S39 R40 Y43 Q46 H49 K50 K52 R119	S39 R40 Y43 Q46 H49 K50 K52 R119

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8k2d, PDBe:8k2d, PDBj:8k2d
PDBsum	8k2d
PubMed	38942792
UniProt	P0CX23\|RL20A_YEAST Large ribosomal subunit protein eL20A (Gene Name=RPL20A)

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