Structure of PDB 8glp Chain LS

Receptor sequence

>8glpLS (length=176) Species: 9606 (Homo sapiens)

MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQ
LKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDL
TTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKI
KFPLPHRVLRRQHKPRFTTKRPNTFF

3D structure

• PDB: 8glp mRNA decoding in human is kinetically and structurally distinct from bacteria.
• Chain: LS
• Resolution: 1.67 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LS	K2 A3 S4 G5 R8 H23 Y63 Q66 V67 F68 E69 K70 P72 S86 R87 S88 H91 M93 Y94 R95 R98 R111 G114 A115 R116 H117 R118 R120 A134 R139 H146 D147 S148 P155 H156 R157 V158 R160 R161 H163 K164 P165 R166 T168 T169 K170 R171 P172 N173 T174 F175 F176	K2 A3 S4 G5 R8 H23 Y63 Q66 V67 F68 E69 K70 P72 S86 R87 S88 H91 M93 Y94 R95 R98 R111 G114 A115 R116 H117 R118 R120 A134 R139 H146 D147 S148 P155 H156 R157 V158 R160 R161 H163 K164 P165 R166 T168 T169 K170 R171 P172 N173 T174 F175 F176
BS02	rna	LS	S42 R43 Y46 S49 K53 K55 S57 R87 R120 H122	S42 R43 Y46 S49 K53 K55 S57 R87 R120 H122
BS03	MG	LS	R95 E96	R95 E96

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8glp, PDBe:8glp, PDBj:8glp
• PDBsum: 8glp
• PubMed: 37020024
• UniProt: Q02543|RL18A_HUMAN Large ribosomal subunit protein eL20 (Gene Name=RPL18A)