Structure of PDB 5wlc Chain LS

Receptor sequence

>5wlcLS (length=481) Species: 1247190 (Saccharomyces cerevisiae BY4741) [Search protein sequence]

PPPDEEEQLLAKFVFGDTTDLQENLAKFNADFEAAWIDSDDEKIKVPILV
TNKTKKLRTSYNESKINGVHYINRLRSQFEKIYPRPKWVDDESDSNGDIN
ALTKILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSF
HPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSN
QNQQNIFTAGRRRYMHSWDLSQTAKIEKFSRLYGHESTQRSFENFKVAHL
QNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQP
ISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGG
TTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQ
LTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLG
KVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY

3D structure

PDB

5wlc The complete structure of the small-subunit processome.

Chain

Resolution

3.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LS	N141 K142 K144 K145 Y150 Q167 D234 I235 Q252 Y268 R317 R318 R319 Y320 K341 S343 R344 E349 R353 N380 N381 T517 R535 K538 D539 T557 S558 G559 T560 P561 G563 K564 E582 Q583	N52 K53 K55 K56 Y61 Q78 D128 I129 Q146 Y162 R211 R212 R213 Y214 K228 S230 R231 E236 R240 N267 N268 T404 R422 K425 D426 T444 S445 G446 T447 P448 G450 K451 E469 Q470

Gene Ontology

	Molecular Function
GO:0003674	molecular_function
GO:0005515	protein binding

	Biological Process
GO:0000292	RNA fragment catabolic process
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364	rRNA processing
GO:0030490	maturation of SSU-rRNA
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0030686	90S preribosome
GO:0032040	small-subunit processome
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5wlc, PDBe:5wlc, PDBj:5wlc
PDBsum	5wlc
PubMed	28945246
UniProt	P40362\|UTP18_YEAST U3 small nucleolar RNA-associated protein 18 (Gene Name=UTP18)

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