Structure of PDB 5lks Chain LS

Receptor sequence

>5lksLS (length=175) Species: 9606 (Homo sapiens)

KASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQL
KKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLT
TAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIK
FPLPHRVLRRQHKPRFTTKRPNTFF

3D structure

• PDB: 5lks Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
• Chain: LS
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LS	A3 S4 G5 Q66 V67 F68 E69 P72 R74 S86 R87 H91 M93 Y94 R95 Y110 R111 G114 A115 R116 H117 R118 R120 R139 S148 P155 H156 V158 R160 R161 H163 R166 T168 T169 K170 R171 P172 T174 F175 F176	A2 S3 G4 Q65 V66 F67 E68 P71 R73 S85 R86 H90 M92 Y93 R94 Y109 R110 G113 A114 R115 H116 R117 R119 R138 S147 P154 H155 V157 R159 R160 H162 R165 T167 T168 K169 R170 P171 T173 F174 F175
BS02	rna	LS	Y46 S49 Q50 K53 K55 K56 S57 R87 R120 H122	Y45 S48 Q49 K52 K54 K55 S56 R86 R119 H121

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5lks, PDBe:5lks, PDBj:5lks
• PDBsum: 5lks
• PubMed: 27665925
• UniProt: Q02543|RL18A_HUMAN Large ribosomal subunit protein eL20 (Gene Name=RPL18A)