Structure of PDB 8xt1 Chain LR

Receptor sequence
>8xt1LR (length=146) Species: 9606 (Homo sapiens) [Search protein sequence]
EVDPVENEAVAPEFTNRNPRNLELLSVARKERGWRTVFPSREFWHRLRVI
RTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQ
RCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE
3D structure
PDB8xt1 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLR
Resolution3.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LR R65 Y178 E179 R32 Y145 E146
BS02 rna LR T85 Q86 H87 H88 R107 K112 N120 V121 W150 S154 S156 T52 Q53 H54 H55 R74 K79 N87 V88 W117 S121 S123
Gene Ontology
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Cellular Component
External links
PDB RCSB:8xt1, PDBe:8xt1, PDBj:8xt1
PDBsum8xt1
PubMed38942792
UniProtA8K9D2

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