Structure of PDB 7mq8 Chain LR

Receptor sequence

>7mq8LR (length=773) Species: 9606 (Homo sapiens)

FKTNYAVERKIEPFYKGGKAQLDQTGQHLFCVCGTRVNILEVASGAVLRS
LEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTA
PVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFH
PDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTM
LSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGL
YFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTA
TADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLK
VFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQ
VMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSNGP
ILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGV
FSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASV
LKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRL
DDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQELDNLLHEKRY
LRALGLAISLDRPHTVLTVIQAIRRDPEACEKLEATMLRLRRDQKEALLR
FCVTWNTNSRHCHEAQAVLGVLLRREAPEELLAYEGVRAALEALLPYTER
HFQRLSRTLQAAAFLDFLWHNMK

3D structure

• PDB: 7mq8 Nucleolar maturation of the human small subunit processome.
• Chain: LR
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LR	R140 Y142 H422 Q442 N724 S725 R726 R773	R130 Y132 H412 Q432 N708 S709 R710 R757

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0034511 U3 snoRNA binding

Biological Process

• GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0030686 90S preribosome
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:7mq8, PDBe:7mq8, PDBj:7mq8
• PDBsum: 7mq8
• PubMed: 34516797
• UniProt: Q12788|TBL3_HUMAN Transducin beta-like protein 3 (Gene Name=TBL3)