Structure of PDB 8xt0 Chain LQ

Receptor sequence
>8xt0LQ (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
ISHGRVFRRMGLGPESRIHLLRNLLTGLVRHERIEAPWARVDEMRGYAEK
LIDYGKLGDTNERAMRMADFWLTEKDLIPKLFQVLAPRYKDQTGGYTRML
QIPNRSLDRAKMAVIEYKGNCLPPLPLPRRDSHLTLLNQLLQGLRQDLRQ
SQ
3D structure
PDB8xt0 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLQ
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LQ I9 S10 H11 G12 R13 V14 R16 R17 L20 G21 H27 R30 N31 H39 E43 A47 R48 T81 E82 R113 L115 D116 R117 K119 I1 S2 H3 G4 R5 V6 R8 R9 L12 G13 H19 R22 N23 H31 E35 A39 R40 T73 E74 R105 L107 D108 R109 K111
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Cellular Component
External links
PDB RCSB:8xt0, PDBe:8xt0, PDBj:8xt0
PDBsum8xt0
PubMed38942792
UniProtQ9NRX2|RM17_HUMAN Large ribosomal subunit protein bL17m (Gene Name=MRPL17)

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