Structure of PDB 8xsx Chain LQ

Receptor sequence

>8xsxLQ (length=187) Species: 9606 (Homo sapiens) [Search protein sequence]

GVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRL
FMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVC
ALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRH
FGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN

3D structure

PDB

8xsx Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

2.4 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LQ	G2 H7 N8 D10 R11 K12 V13 R14 R15 S20 K30 F34 R37 R38 T42 F43 M53 S54 R55 T56 N57 S62 S64 R65 R68 K69 L72 P73 R75 K78 T85 T87 D88 D89 V90 R91 V92 R104 T106 S107 R108 G133 C134 G135 T136 L138 L139 S140 P142 R143 K144 G145 R146 V148 R150 F152 T158 P159 H160 H162 K164 P165 Y166 R168 S169 K170 K173 F174 E175 R176 R178 R180 R181 S183 R184 G185 Y186 K187 N188	G1 H6 N7 D9 R10 K11 V12 R13 R14 S19 K29 F33 R36 R37 T41 F42 M52 S53 R54 T55 N56 S61 S63 R64 R67 K68 L71 P72 R74 K77 T84 T86 D87 D88 V89 R90 V91 R103 T105 S106 R107 G132 C133 G134 T135 L137 L138 S139 P141 R142 K143 G144 R145 V147 R149 F151 T157 P158 H159 H161 K163 P164 Y165 R167 S168 K169 K172 F173 E174 R175 R177 R179 R180 S182 R183 G184 Y185 K186 N187

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0043232	intracellular non-membrane-bounded organelle
GO:1990904	ribonucleoprotein complex

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Cellular Component

External links

PDB	RCSB:8xsx, PDBe:8xsx, PDBj:8xsx
PDBsum	8xsx
PubMed	38942792
UniProt	Q07020\|RL18_HUMAN Large ribosomal subunit protein eL18 (Gene Name=RPL18)

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