Structure of PDB 8brm Chain LQ

Receptor sequence

>8brmLQ (length=153) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence]

VKYAFKSDNLLVGKSRRDGVKASFKNTYSTCRAIKGMGVKRAFAYLDNVL
NHKEIVPFFKFYKGVGRHSQARGSGTDKGRWPEKSVVVVKDILKQAVSNA
KHAHKKEEDELYVISYCVNRARGRRRRTFRAHGRISKYESQPCHVELIVG
PKP

3D structure

PDB

8brm Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.

Chain

Resolution

3.33 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LQ	V2 K3 A5 R33 F60 K61 Y63 N120 R123 H145	V1 K2 A4 R32 F59 K60 Y62 N119 R122 H144
BS02	rna	LQ	Y4 K15 S16 R17 R18 S24 K26 Y29 R42 K61 F62 Y63 K64 G65 G67 R68 H69 S70 Q71 R73 D78 R81 W82 E84 K85 D92 K95 Q96 S99 H103 Y117 V119 N120 R121 R125 R127 R128 F130 R131 A132 H133 G134 I136 S137 K138 Y139 E140 S141 Q142	Y3 K14 S15 R16 R17 S23 K25 Y28 R41 K60 F61 Y62 K63 G64 G66 R67 H68 S69 Q70 R72 D77 R80 W81 E83 K84 D91 K94 Q95 S98 H102 Y116 V118 N119 R120 R124 R126 R127 F129 R130 A131 H132 G133 I135 S136 K137 Y138 E139 S140 Q141

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8brm, PDBe:8brm, PDBj:8brm
PDBsum	8brm
PubMed	36912103
UniProt	A8BE76

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