Structure of PDB 5lks Chain LQ

Receptor sequence

>5lksLQ (length=187) Species: 9606 (Homo sapiens)

GVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRL
FMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVC
ALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRH
FGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN

3D structure

• PDB: 5lks Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
• Chain: LQ
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LQ	G2 D10 R11 V13 R14 R15 K19 S20 R26 K30 F34 R37 R38 T42 K49 M53 S54 R55 T56 S62 S64 R65 R68 L72 P73 R75 T85 T87 D88 D89 V90 R91 R104 T106 R108 R115 C134 G135 L138 S140 R143 K144 G145 R150 F152 T158 P159 H162 K164 P165 R172 K173 E175 R181 S183 R184 Y186 K187	G1 D9 R10 V12 R13 R14 K18 S19 R25 K29 F33 R36 R37 T41 K48 M52 S53 R54 T55 S61 S63 R64 R67 L71 P72 R74 T84 T86 D87 D88 V89 R90 R103 T105 R107 R114 C133 G134 L137 S139 R142 K143 G144 R149 F151 T157 P158 H161 K163 P164 R171 K172 E174 R180 S182 R183 Y185 K186

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005791 rough endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0043232 intracellular non-membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5lks, PDBe:5lks, PDBj:5lks
• PDBsum: 5lks
• PubMed: 27665925
• UniProt: Q07020|RL18_HUMAN Large ribosomal subunit protein eL18 (Gene Name=RPL18)