Structure of PDB 5lks Chain LP

Receptor sequence

>5lksLP (length=153) Species: 9606 (Homo sapiens)

VRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDV
TLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESN
AELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILT
EKE

3D structure

• PDB: 5lks Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
• Chain: LP
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LP	V2 Y4 K16 S17 R18 S20 R23 H25 K27 N28 R30 Q34 K37 K43 K55 Q56 R62 Y63 N64 G65 G66 R69 A71 Q72 Q75 Q80 R82 W83 K86 N97 S100 N101 L104 Q118 R127 Y130 R131 A132 H133 I136 N137 P138 Y139 M140 S141	V1 Y3 K15 S16 R17 S19 R22 H24 K26 N27 R29 Q33 K36 K42 K54 Q55 R61 Y62 N63 G64 G65 R68 A70 Q71 Q74 Q79 R81 W82 K85 N96 S99 N100 L103 Q117 R126 Y129 R130 A131 H132 I135 N136 P137 Y138 M139 S140
BS02	rna	LP	R3 S5 R61 R62 N120 K121	R2 S4 R60 R61 N119 K120
BS03	MG	LP	Y130 R131	Y129 R130

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5lks, PDBe:5lks, PDBj:5lks
• PDBsum: 5lks
• PubMed: 27665925
• UniProt: P18621|RL17_HUMAN Large ribosomal subunit protein uL22 (Gene Name=RPL17)