Structure of PDB 7mq9 Chain LO

Receptor sequence

>7mq9LO (length=848) Species: 9606 (Homo sapiens)

KFAYRFSNLLGTVYRRGNLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLP
LATRYNVKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVHS
VSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCID
WTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSL
DLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQRKVKYSRLAKYFF
NKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQS
IASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYS
PDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVT
SSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFE
IFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFD
SWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIE
GRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSILAGGMSKFVCIY
HVREQILMKRFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGQEDGV
AIPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDT
RVLFDPFELDTSVTPGRVREALRQQDFTRAILMALRLNESKLVQEALEAV
PRGEIEVVTSSLPELYVEKVLEFLASSFEVSRHLEFYLLWTHKLLMLHGQ
KLKSRAGTLLPVIQFLQKSIQRHLDDLSKLCSWNHYNMQYALAVSKQR

3D structure

• PDB: 7mq9 Nucleolar maturation of the human small subunit processome.
• Chain: LO
• Resolution: 3.87 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LO	Y56 G76 I118 T139 F141 R175 I180 Y181 Y182 K188 D209 K227 K271 F281 E285 G286 D287 F288 R661 D673	Y55 G75 I117 T138 F140 R174 I179 Y180 Y181 K187 D208 K226 K239 F249 E253 G254 D255 F256 R629 D641
BS02	rna	LO	D443 R446 F450 R451 T452 S533 W534	D411 R414 F418 R419 T420 S501 W502
BS03	rna	LO	R591 T598 H601 F657 L658 M663	R559 T566 H569 F625 L626 M631

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0031981 nuclear lumen
• GO:0032040 small-subunit processome
• GO:0034388 Pwp2p-containing subcomplex of 90S preribosome

External links

• PDB: RCSB:7mq9, PDBe:7mq9, PDBj:7mq9
• PDBsum: 7mq9
• PubMed: 34516797
• UniProt: Q15269|PWP2_HUMAN Periodic tryptophan protein 2 homolog (Gene Name=PWP2)