Structure of PDB 8xsy Chain LN

Receptor sequence

>8xsyLN (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]

GAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRL
GYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSV
AEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWI
TKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLH
RYR

3D structure

PDB

8xsy Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

3.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LN	G2 Y4 K5 Q8 W11 R12 K14 Q15 R24 W28 R31 P40 R41 R44 K47 R49 R50 L51 A55 K56 Q57 R65 R67 R68 G69 G70 K72 R73 P74 K77 G78 Y81 G82 K83 V85 H86 H87 V89 N90 Q91 K93 F94 A95 R96 S97 E104 R105 R108 A112 W120 S125 Y127 K128 F138 K140 R144 W150 H156 K157 H158 M161 R162 L164 S166 R169 K170 S171 R172 K176 G177 H178 K179 H181 H182 I184 G186 S187 R189 W192 R193 R194 R195 Q199 H201 R202 Y203 R204	G1 Y3 K4 Q7 W10 R11 K13 Q14 R23 W27 R30 P39 R40 R43 K46 R48 R49 L50 A54 K55 Q56 R64 R66 R67 G68 G69 K71 R72 P73 K76 G77 Y80 G81 K82 V84 H85 H86 V88 N89 Q90 K92 F93 A94 R95 S96 E103 R104 R107 A111 W119 S124 Y126 K127 F137 K139 R143 W149 H155 K156 H157 M160 R161 L163 S165 R168 K169 S170 R171 K175 G176 H177 K178 H180 H181 I183 G185 S186 R188 W191 R192 R193 R194 Q198 H200 R201 Y202 R203
BS02	rna	LN	R38 Q57 V60 Y62 H109 C110 L113 D136 H139	R37 Q56 V59 Y61 H108 C109 L112 D135 H138

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0045296	cadherin binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0045471	response to ethanol

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0031672	A band
GO:0044391	ribosomal subunit
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8xsy, PDBe:8xsy, PDBj:8xsy
PDBsum	8xsy
PubMed	38942792
UniProt	P61313\|RL15_HUMAN Large ribosomal subunit protein eL15 (Gene Name=RPL15)

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