Structure of PDB 8k82 Chain LL

Receptor sequence

>8k82LL (length=194) Species: 4932 (Saccharomyces cerevisiae)

AISKNLPILKNHFRKHWQERVKVHFDQAGKKVSRRNARATRAAKIAPRPL
DLLRPVVRAPTVKYNRKVRAGRGFTLAEVKAAGLTAAYARTIGIAVDHRR
QNRNQEIFDANVQRLKEYQSKIIVFPRNGKAPEAEQVLSAAATFPIAQPA
TDVEARAVQDNGESAFRTLRLARSEKKFRGIREKRAREKAEAEA

3D structure

• PDB: 8k82 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
• Chain: LL
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LL	A2 I3 S4 K5 L7 L10 K11 N12 H13 F14 R15 K16 H17 W18 Q19 Q28 A29 K31 K32 R35 R36 R39 R42 R55 V58 R59 P61 Y65 N66 K68 R70 R73 R91 D98 H99 R100 R101 R104 N105 G130 E134 F167 R168 R171 R174 S175 K178 F179 R180 R183 K185 R186	A1 I2 S3 K4 L6 L9 K10 N11 H12 F13 R14 K15 H16 W17 Q18 Q27 A28 K30 K31 R34 R35 R38 R41 R54 V57 R58 P60 Y64 N65 K67 R69 R72 R90 D97 H98 R99 R100 R103 N104 G129 E133 F166 R167 R170 R173 S174 K177 F178 R179 R182 K184 R185
BS02	rna	LL	F26 S34	F25 S33

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8k82, PDBe:8k82, PDBj:8k82
• PDBsum: 8k82
• PubMed: 38942792
• UniProt: Q12690|RL13A_YEAST Large ribosomal subunit protein eL13A (Gene Name=RPL13A)