Structure of PDB 8g60 Chain LL

Receptor sequence

>8g60LL (length=206) Species: 9606 (Homo sapiens) [Search protein sequence]

APSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPA
SGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPR
RRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLT
GPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKE
AAEQDV

3D structure

PDB

8g60 mRNA decoding in human is kinetically and structurally distinct from bacteria.

Chain

Resolution

2.54 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	LL	F26 N27 A30 R34	F25 N26 A29 R33
BS02	rna	LL	A2 R5 M8 L10 K11 P12 H13 F14 H15 K16 W18 Q19 R20 W25 Q28 P29 R31 K32 I33 R35 R36 K37 R39 K42 R44 R56 V59 R60 C61 P62 T63 V64 Y66 H67 K69 R71 G73 R74 L78 K88 R92 D99 P100 R101 R102 R103 K105 S106 R129 K136 R221 K226 K228 F242 R246 M247 R249 A250 N251 R253 L254 G256 R258 K260 R261	A1 R4 M7 L9 K10 P11 H12 F13 H14 K15 W17 Q18 R19 W24 Q27 P28 R30 K31 I32 R34 R35 K36 R38 K41 R43 R55 V58 R59 C60 P61 T62 V63 Y65 H66 K68 R70 G72 R73 L77 K87 R91 D98 P99 R100 R101 R102 K104 S105 R128 K135 R157 K162 K164 F178 R182 M183 R185 A186 N187 R189 L190 G192 R194 K196 R197
BS03	MG	LL	R103 K105	R102 K104

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0001824	blastocyst development
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0060348	bone development

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8g60, PDBe:8g60, PDBj:8g60
PDBsum	8g60
PubMed	37020024
UniProt	P26373\|RL13_HUMAN Large ribosomal subunit protein eL13 (Gene Name=RPL13)

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