Structure of PDB 8xt0 Chain LK

Receptor sequence
>8xt0LK (length=175) Species: 9606 (Homo sapiens) [Search protein sequence]
GVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKEGIPLP
TKILVKPDRTFEIKIGQPTVSYFLKAAAGIEKGARQTGKEVAGLVTLKHV
YEIARIKAQDEAFALQDVPLSSVVRSIIGSARSLGIRVVKDLSSEELAAF
QKERAIFLAAQKEADLAAQEEAAKK
3D structure
PDB8xt0 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLK
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LK R21 A22 I23 V38 K99 G100 A101 R102 Q103 T104 K106 K124 Q133 V135 S139 R142 S143 G146 S147 R149 S150 L151 R4 A5 I6 V21 K82 G83 A84 R85 Q86 T87 K89 K107 Q116 V118 S122 R125 S126 G129 S130 R132 S133 L134
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt0, PDBe:8xt0, PDBj:8xt0
PDBsum8xt0
PubMed38942792
UniProtQ9Y3B7|RM11_HUMAN Large ribosomal subunit protein uL11m (Gene Name=MRPL11)

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