Structure of PDB 8flc Chain LK

Receptor sequence

>8flcLK (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]

PSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGLHHHRINFDKYHPG
YFGKVGMKHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPII
DVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKSVGGACVLVA

3D structure

PDB

8flc Principles of human pre-60 S biogenesis.

Chain

Resolution

2.76 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LK	P2 S3 R4 R6 K7 T8 R9 K10 R12 G13 H14 V15 S16 H17 G18 G20 R21 I22 R26 K27 G31 R32 G33 N34 G36 H39 H40 H41 R42 I43 N44 Y52 F53 G54 K55 V56 G57 M58 K59 H60 Y61 H62 L63 R65 N66 T72 N74 K77 S83 Q85 T86 D102 R105 K110 L112 G113 K114 G115 K116 S130 R131 R132	P1 S2 R3 R5 K6 T7 R8 K9 R11 G12 H13 V14 S15 H16 G17 G19 R20 I21 R25 K26 G30 R31 G32 N33 G35 H38 H39 H40 R41 I42 N43 Y51 F52 G53 K54 V55 G56 M57 K58 H59 Y60 H61 L62 R64 N65 T71 N73 K76 S82 Q84 T85 D101 R104 K109 L111 G112 K113 G114 K115 S129 R130 R131

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8flc, PDBe:8flc, PDBj:8flc
PDBsum	8flc
PubMed	37410842
UniProt	P46776\|RL27A_HUMAN Large ribosomal subunit protein uL15 (Gene Name=RPL27A)