Structure of PDB 7xny Chain LJ

Receptor sequence

>7xnyLJ (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]

NPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRS
FGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGI
QEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISK
EEAMRWFQQKYDGIILPGK

3D structure

PDB

7xny A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LJ	K19 C21 N23 C25 S51 A53 R54 S59 F60 I62 H71 N97 N98 D101 T102 N104 G106 F107 G108 G127 D129 Y131 K145	K10 C12 N14 C16 S42 A44 R45 S50 F51 I53 H62 N88 N89 D92 T93 N95 G97 F98 G99 G118 D120 Y122 K136
BS02	rna	LJ	N10 M12 R13 Q46 T47 V49 T73 R75 G138 I141 R147 C150 I151 A153 K154 H155 R156	N1 M3 R4 Q37 T38 V40 T64 R66 G129 I132 R138 C141 I142 A144 K145 H146 R147

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006605	protein targeting
GO:0010628	positive regulation of gene expression
GO:0032092	positive regulation of protein binding
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0042273	ribosomal large subunit biogenesis
GO:0050821	protein stabilization
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1901798	positive regulation of signal transduction by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7xny, PDBe:7xny, PDBj:7xny
PDBsum	7xny
PubMed	36259929
UniProt	P62913\|RL11_HUMAN Large ribosomal subunit protein uL5 (Gene Name=RPL11)

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