Structure of PDB 7cpv Chain LJ

Receptor sequence

>7cpvLJ (length=171) Species: 10090 (Mus musculus) [Search protein sequence]

GEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARY
TVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNF
GFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKH
RISKEEAMRWFQQKYDGIILP

3D structure

PDB

7cpv A male germ-cell-specific ribosome controls male fertility.

Chain

Resolution

3.03 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LJ	C21 N23 C25 S51 A53 R54 Y55 F60 I62 N97 N98 S100 D101 T102 N104 G106 F107 G108 G127 L128 D129 Y131 K145	C16 N18 C20 S46 A48 R49 Y50 F55 I57 N92 N93 S95 D96 T97 N99 G101 F102 G103 G122 L123 D124 Y126 K140
BS02	rna	LJ	N10 M12 Q46 T47 V49 T73 R75 G138 S140 I141 D143 R146 R147 C150 I151 G152 A153 K154 H155	N5 M7 Q41 T42 V44 T68 R70 G133 S135 I136 D138 R141 R142 C145 I146 G147 A148 K149 H150

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006605	protein targeting
GO:0010628	positive regulation of gene expression
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0042273	ribosomal large subunit biogenesis
GO:0050821	protein stabilization
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1901798	positive regulation of signal transduction by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7cpv, PDBe:7cpv, PDBj:7cpv
PDBsum	7cpv
PubMed	36517592
UniProt	Q9CXW4\|RL11_MOUSE Large ribosomal subunit protein uL5 (Gene Name=Rpl11)

[Back to BioLiP]