Structure of PDB 7bhp Chain LJ

Receptor sequence

>7bhpLJ (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]

KENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTV
RSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGF
GIQEHIDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAM
RWFQQKYDGII

3D structure

PDB

7bhp Dynamic association of human Ebp1 with the ribosome.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LJ	K19 C21 N23 C25 A53 F60 I68 N97 N98 D101 N104 G106 F107 G108 I109 Q110 G127 L128 D129 Y131 K145	K12 C14 N16 C18 A46 F53 I61 N90 N91 D94 N97 G99 F100 G101 I102 Q103 G114 L115 D116 Y118 K132
BS02	rna	LJ	K8 P11 M12 R13 Q46 T47 V49 T73 R75 P137 S140 I141 D143 K144 R147 C150 I151 H155 R156	K1 P4 M5 R6 Q39 T40 V42 T66 R68 P124 S127 I128 D130 K131 R134 C137 I138 H142 R143

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006605	protein targeting
GO:0010628	positive regulation of gene expression
GO:0032092	positive regulation of protein binding
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0042273	ribosomal large subunit biogenesis
GO:0050821	protein stabilization
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1901798	positive regulation of signal transduction by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7bhp, PDBe:7bhp, PDBj:7bhp
PDBsum	7bhp
PubMed	33479117
UniProt	P62913\|RL11_HUMAN Large ribosomal subunit protein uL5 (Gene Name=RPL11)

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