Structure of PDB 8oj8 Chain LI

Receptor sequence

>8oj8LI (length=202) Species: 9606 (Homo sapiens)

GRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGH
MVSDEYEQLSSEALEAARICANKYMVKSCGRDGFHIRVRLHPFHVIRINK
MGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGR
QKIHISKKWGFTKFNADEFEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVL
HS

3D structure

• PDB: 8oj8 UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
• Chain: LI
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LI	R3 R4 A6 R7 C8 K13 N14 K15 P16 Y17 F22 R24 D35 S61 E63 A64 R90 H92 F94 R98 M102 M115 R116 A118 F119 Q133 F157 K158 P160 D193 G194 K198	R2 R3 A5 R6 C7 K12 N13 K14 P15 Y16 F21 R23 D34 S60 E62 A63 R89 H91 F93 R97 M101 M103 R104 A106 F107 Q121 F145 K146 P148 D181 G182 K186
BS02	rna	LI	Y11 E56 I131 S202 H203 G204 L206	Y10 E55 I119 S190 H191 G192 L194

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation
• GO:0007141 male meiosis I
• GO:0007283 spermatogenesis
• GO:0030154 cell differentiation
• GO:0051321 meiotic cell cycle

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8oj8, PDBe:8oj8, PDBj:8oj8
• PDBsum: 8oj8
• PubMed: 38383785
• UniProt: Q96L21|RL10L_HUMAN Ribosomal protein uL16-like (Gene Name=RPL10L)