Structure of PDB 8fkq Chain LI

Receptor sequence

>8fkqLI (length=134) Species: 9606 (Homo sapiens) [Search protein sequence]

MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIR
KDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIH
PSKVVITRLKLDKDRKKILERKAKSRQVGKEKGK

3D structure

PDB

8fkq Principles of human pre-60 S biogenesis.

Chain

Resolution

2.76 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LI	R11 R15 K16 F19 S23 H24 R27 R50 K51 Q72 V73 Y74 R75 K76 K113 D114 I118	R11 R15 K16 F19 S23 H24 R27 R50 K51 Q72 V73 Y74 R75 K76 K113 D114 I118
BS02	rna	LI	M1 K2 F3 N4 P5 T8 S9 R11 K13 N14 R15 R17 H18 K28 S31 P33 K36 R45 S46 R59 G60 H61 R87 K89 A90 H100 S102 K103 R121 K122 S125 R126	M1 K2 F3 N4 P5 T8 S9 R11 K13 N14 R15 R17 H18 K28 S31 P33 K36 R45 S46 R59 G60 H61 R87 K89 A90 H100 S102 K103 R121 K122 S125 R126

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0048027	mRNA 5'-UTR binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0034644	cellular response to UV
GO:0042273	ribosomal large subunit biogenesis
GO:0045727	positive regulation of translation
GO:0071479	cellular response to ionizing radiation
GO:0071480	cellular response to gamma radiation
GO:1902164	positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1904803	regulation of translation involved in cellular response to UV

	Cellular Component
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8fkq, PDBe:8fkq, PDBj:8fkq
PDBsum	8fkq
PubMed	37410842
UniProt	P61254\|RL26_HUMAN Large ribosomal subunit protein uL24 (Gene Name=RPL26)