Structure of PDB 6zmi Chain LI

Receptor sequence

>6zmiLI (length=202) Species: 9606 (Homo sapiens)

GRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGH
MVSDEYEQLSSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINK
MGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGR
QKIHISKKWGFTKFNADEFEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVL
HS

3D structure

• PDB: 6zmi Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
• Chain: LI
• Resolution: 2.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LI	R3 R4 A6 R7 C8 K13 N14 K15 Y17 F22 K30 D35 K39 E63 A64 A67 K74 R90 H92 F94 R98 M115 R116 G117 A118 F119 G120 Q133 R154 F157 K158 P160 R162 G194 C195 K198	R2 R3 A5 R6 C7 K12 N13 K14 Y16 F21 K29 D34 K38 E62 A63 A66 K73 R89 H91 F93 R97 M103 R104 G105 A106 F107 G108 Q121 R142 F145 K146 P148 R150 G182 C183 K186
BS02	rna	LI	Y11 E56 Y57 Y199 S202 H203 G204 L206 W209	Y10 E55 Y56 Y187 S190 H191 G192 L194 W197

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation
• GO:0007141 male meiosis I
• GO:0007283 spermatogenesis
• GO:0030154 cell differentiation
• GO:0051321 meiotic cell cycle

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zmi, PDBe:6zmi, PDBj:6zmi
• PDBsum: 6zmi
• PubMed: 32680882
• UniProt: Q96L21|RL10L_HUMAN Ribosomal protein uL16-like (Gene Name=RPL10L)