Structure of PDB 6qzp Chain LI

Receptor sequence

>6qzpLI (length=213) Species: 9606 (Homo sapiens)

GRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGH
MVSDEYEQLSSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINK
MLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNEEHVIEA
LRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAKKCLIPDGCGVKYVP
SHGPLDKWRVLHS

3D structure

• PDB: 6qzp Visualization of chemical modifications in the human 80S ribosome structure.
• Chain: LI
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LI	R3 R4 A6 R7 C8 Y9 K13 K15 Y17 F22 K30 F34 D35 K39 K40 E63 A64 A67 K74 R90 H92 F94 R98 I99 N100 L103 A108 L111 M115 R116 A118 F119 G120 F157 K158 P160 R162 G194 K198	R2 R3 A5 R6 C7 Y8 K12 K14 Y16 F21 K29 F33 D34 K38 K39 E62 A63 A66 K73 R89 H91 F93 R97 I98 N99 L102 A107 L110 M114 R115 A117 F118 G119 F156 K157 P159 R161 G193 K197
BS02	rna	LI	Y11 Y57 Y199 S202 H203 G204 L206	Y10 Y56 Y198 S201 H202 G203 L205

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation
• GO:0007141 male meiosis I
• GO:0007283 spermatogenesis
• GO:0030154 cell differentiation
• GO:0051321 meiotic cell cycle

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6qzp, PDBe:6qzp, PDBj:6qzp
• PDBsum: 6qzp
• PubMed: 29143818
• UniProt: Q96L21|RL10L_HUMAN Ribosomal protein uL16-like (Gene Name=RPL10L)