Structure of PDB 8xsz Chain LH

Receptor sequence

>8xszLH (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]

MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGK
KKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFP
INVVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGND
IELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQA

3D structure

PDB

8xsz Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

3.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LH	G22 R23 H40 V43 E44 K50 K52 K59 W60 R64 K65 A68 R71 T72 S75 H76 N79 H98 F99 E120 K121 Y122 R129 I151 E152 S155 Q163 K170 D171 R173 K174 F175	G22 R23 H40 V43 E44 K50 K52 K59 W60 R64 K65 A68 R71 T72 S75 H76 N79 H98 F99 E120 K121 Y122 R129 I151 E152 S155 Q163 K170 D171 R173 K174 F175

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8xsz, PDBe:8xsz, PDBj:8xsz
PDBsum	8xsz
PubMed	38942792
UniProt	P32969\|RL9_HUMAN Large ribosomal subunit protein uL6 (Gene Name=RPL9)

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