Structure of PDB 7mqa Chain LH

Receptor sequence

>7mqaLH (length=746) Species: 9606 (Homo sapiens)

IRVVRCGGSELNFRRAVFSADSKYIFCVSGDFVKVYSTVTEECVHILHGH
RNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALF
TLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQ
SPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLSSSRNKKHAKNNF
TCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAF
SVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFC
TSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPG
HLQFYSLQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVE
QRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKS
EQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCF
SEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSKYL
LGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSD
LFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFTSEAYQWLNRSQF
YFLTKSQSLLTFSTKTTPFYFILGKHRNELVQLPLTENIPAISELLHTPA
HVLPSAAFLCSMFVNSLLLSKDIIHQLSKSEEKELRKFRKIDYSWI

3D structure

• PDB: 7mqa Nucleolar maturation of the human small subunit processome.
• Chain: LH
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LH	K200 H201 K237 Y239 Y241 C243 H245 W246 H247 H248 E280 F285 P287 R288 D382	K194 H195 K231 Y233 Y235 C237 H239 W240 H241 H242 E274 F279 P281 R282 D376

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis
• GO:0045943 positive regulation of transcription by RNA polymerase I
• GO:2000234 positive regulation of rRNA processing

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
• PDBsum: 7mqa
• PubMed: 34516797
• UniProt: Q8IWA0|WDR75_HUMAN WD repeat-containing protein 75 (Gene Name=WDR75)