Structure of PDB 7nrc Chain LG

Receptor sequence

>7nrcLG (length=294) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

QKDAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTPKYRLVV
RFTNKDIICQIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYATGL
LIARRTLQKLGLDETYKGVEEVEGEYELTEAVEDGPRPFKVFLDIGLQRT
TTGARVFGALKGASDGGLYVPHSENRFPGWDFETEEIDPELLRSYIFGGH
VSQYMEELADDDEERFSELFKGYLADDIDADSLEDIYTSAHEAIRADPAF
KPTEKKFTKEQYAAESKKYRQTKLSKEERAARVAAKIAALAGQQ

3D structure

PDB

7nrc Structure of Gcn1 bound to stalled and colliding 80S ribosomes.

Chain

Resolution

3.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LG	K8 A11 Y12 R15 F16 Q17 P19 R23 T28 D29 Q32 R35 L36 K43 Y44 T46 K48 P139 R140 P141 F142 F145 I148 L150 R152 T153 H175 S176 N178 R179	K5 A8 Y9 R12 F13 Q14 P16 R20 T25 D26 Q29 R32 L33 K40 Y41 T43 K45 P136 R137 P138 F139 F142 I145 L147 R149 T150 H172 S173 N175 R176
BS02	rna	LG	S13 S14 F16 T18 F20 R21 R22 R24 R33 R50 V52 R54 T56 N57 K58 D59 I69 T70 D72 V74 H90 G91 N94 Q151 R152 G156 A157 R158 Y198 H203 Q206 Y207 E210 E221 L222 F223 K224 F253 T256 K258 K259 F260 K262 Q264 Y265 A266 E268 S269 K270 Y272 Q274 K276 L277 R282 K289	S10 S11 F13 T15 F17 R18 R19 R21 R30 R47 V49 R51 T53 N54 K55 D56 I66 T67 D69 V71 H87 G88 N91 Q148 R149 G153 A154 R155 Y195 H200 Q203 Y204 E207 E218 L219 F220 K221 F250 T253 K255 K256 F257 K259 Q261 Y262 A263 E265 S266 K267 Y269 Q271 K273 L274 R279 K286

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7nrc, PDBe:7nrc, PDBj:7nrc
PDBsum	7nrc
PubMed	33790014
UniProt	P26321\|RL5_YEAST Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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