Structure of PDB 6z6l Chain LG

Receptor sequence

>6z6lLG (length=241) Species: 9606 (Homo sapiens)

KVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLK
VPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGK
GDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCR
KMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTN
YNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG

3D structure

• PDB: 6z6l Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
• Chain: LG
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LG	E33 K34 R35 K37 F39 I41 Q43 D44 I45 Q46 P47 L51 R53 F54 V55 K56 P58 R59 Y60 I69 K72 R73 L74 Q108 K110 K111 R113 R132 P133 G139 V140 N141 T142 P163 L166 K187 A188 R196 K197 T198 T200 P244 K245 S246	E8 K9 R10 K12 F14 I16 Q18 D19 I20 Q21 P22 L26 R28 F29 V30 K31 P33 R34 Y35 I44 K47 R48 L49 Q83 K85 K86 R88 R107 P108 G114 V115 N116 T117 P138 L141 K162 A163 R171 K172 T173 T175 P219 K220 S221
BS02	rna	LG	Y60 I61 Q64 R65 R89 H159 D160 K185 R189	Y35 I36 Q39 R40 R64 H134 D135 K160 R164

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0045296 cadherin binding

Biological Process

• GO:0000470 maturation of LSU-rRNA
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6z6l, PDBe:6z6l, PDBj:6z6l
• PDBsum: 6z6l
• PubMed: 32687489
• UniProt: P62424|RL7A_HUMAN Large ribosomal subunit protein eL8 (Gene Name=RPL7A)