Structure of PDB 5lks Chain LF

Receptor sequence

>5lksLF (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]

NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMAR
MARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFV
KLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNA
LIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKK
TTHFVEGGDAGNREDQINRLIRRMN

3D structure

PDB

5lks Structure-function insights reveal the human ribosome as a cancer target for antibiotics.

Chain

Resolution

3.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	LF	K31 R32 L33 R34 K36 F37 Q39 M41 L42 R43 A45 R46 K48 L49 Y51 K55 H58 R62 Q63 I69 R70 R73 M74 R76 R96 G97 I98 N99 S102 P103 K104 K107 L111 Q116 K124 A128 N131 M132 N146 L147 K165 R166 R177 G180 I185 K202 N206 K212 S215 P216 R217 G218 G219 M220 K221 K222 K223 R242	K8 R9 L10 R11 K13 F14 Q16 M18 L19 R20 A22 R23 K25 L26 Y28 K32 H35 R39 Q40 I46 R47 R50 M51 R53 R73 G74 I75 N76 S79 P80 K81 K84 L88 Q93 K101 A105 N108 M109 N123 L124 K142 R143 R154 G157 I162 K179 N183 K189 S192 P193 R194 G195 G196 M197 K198 K199 K200 R219
BS02	rna	LF	R134 K222 H226 V228 E229	R111 K199 H203 V205 E206

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0042802	identical protein binding

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0042273	ribosomal large subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5lks, PDBe:5lks, PDBj:5lks
PDBsum	5lks
PubMed	27665925
UniProt	P18124\|RL7_HUMAN Large ribosomal subunit protein uL30 (Gene Name=RPL7)

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